DISEASES

Disease-gene associations mined from literature

Literature on NDST3

NDST3 [ENSP00000296499]

Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3; Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has high deacetylase activity but low sulfotransferase activity.

Synonyms:  NDST3,  NDST3p,  hNDST3,  O95803,  O95803p ...

Linkouts:  STRING  Pharos  UniProt  OMIM