DISEASES

Disease-gene associations mined from literature

Literature on TMEM97

TMEM97 [ENSP00000226230]

Sigma intracellular receptor 2; Intracellular orphan receptor that binds numerous drugs and which is highly expressed in various proliferating cancer cells . Corresponds to the sigma-2 receptor, which is thought to play important role in regulating cell survival, morphology and differentiation . Under investigation for its potential diagnostic and therapeutic uses . May play a role as a regulator of cellular cholesterol homeostasis . May function as sterol isomerase . May alter the activity of some cytochrome P450 proteins . ECO:0000303|PubMed:22292588, ECO:0000303|PubMed:23922215,

Synonyms:  TMEM97,  TMEM97p,  hTMEM97,  J3KT68,  J3KTD1 ...

Linkouts:  STRING  Pharos  UniProt  OMIM