DISEASES

Disease-gene associations mined from literature

Literature on SH3PXD2A

SH3PXD2A [ENSP00000348215]

SH3 and PX domain-containing protein 2A; Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide. ECO:0000269|PubMed:15710328, ECO:0000269|PubMed:15710903,; Belongs to the SH3PXD2 family.

Synonyms:  SH3PXD2A,  H0Y507,  Q5TCZ1,  H0Y507p,  hH0Y507 ...

Linkouts:  STRING  Pharos  UniProt