DISEASES

Disease-gene associations mined from literature

Literature on NRDE2

NRDE2 [ENSP00000346335]

Nuclear exosome regulator NRDE2; Protein of the nuclear speckles that regulates RNA degradation and export from the nucleus through its interaction with MTREX an essential factor directing various RNAs to exosomal degradation . Changes the conformation of MTREX, precluding its association with the nuclear exosome and interaction with proteins required for its function in RNA exosomal degradation . Negatively regulates, for instance, the degradation of mRNAs and lncRNAs by inhibiting their MTREX-mediated recruitment to nuclear exosome . By preventing the degradation of RNAs in the nucleus, it promotes their export to the cytoplasm ; Belongs to the NRDE2 family.

Synonyms:  NRDE2,  NRDE2p,  hNRDE2,  G3V338,  H0YJT0 ...

Linkouts:  STRING  Pharos  UniProt