DISEASES

Disease-gene associations mined from literature

Literature on OSBP

OSBP [ENSP00000263847]

Oxysterol-binding protein 1; Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum . Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol . Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25- hydroxycholesterol causes its disassembly . Regulates cholesterol efflux by decreasing ABCA1 stability . ; Belongs to the OSBP family.

Synonyms:  OSBP,  H0YCV6,  P22059,  H0YCV6p,  hH0YCV6 ...

Linkouts:  STRING  Pharos  UniProt  OMIM