DISEASES

Disease-gene associations mined from literature

Literature on OSBPL8

OSBPL8 [ENSP00000261183]

Oxysterol-binding protein-related protein 8; Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner . Binds oxysterol, 25- hydroxycholesterol and cholesterol (PubMed:17428193, PubMed:17991739, PubMed:21698267). ECO:0000269|PubMed:17991739, ECO:0000269|PubMed:21698267,; Belongs to the OSBP family.

Synonyms:  OSBPL8,  OSBPL8p,  hOSBPL8,  A0A024RBB8,  F8VQX7 ...

Linkouts:  STRING  Pharos  UniProt  OMIM