Literature on EDEM1
EDEM1 [ENSP00000256497]
ER degradation-enhancing alpha-mannosidase-like protein 1; Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. It is directly involved in endoplasmic reticulum-associated degradation (ERAD) and targets misfolded glycoproteins for degradation in an N-glycan- independent manner, probably by forming a complex with SEL1L. It has low mannosidase activity, catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2. ECO:0000269|PubMed:19524542, ECO:0000269|PubMed:19934218,; Belongs to the glycosyl hydrolase 47 family.
Synonyms: EDEM1, EDEM1p, hEDEM1, A0A024R2D5, F8WE67 ...