DISEASES

Disease-gene associations mined from literature

Literature on DHPS

DHPS [ENSP00000210060]

Deoxyhypusine synthase; Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a critical lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue . This is the first step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function.

Synonyms:  DHPS,  A0A024R7D0,  A0A024R7E9,  A0A087WZK0,  B4E3M2 ...

Linkouts:  STRING  Pharos  UniProt  OMIM