DISEASES

Disease-gene associations mined from literature

Literature on RAB3IP

RAB3IP [ENSP00000447300]

Rab-3A-interacting protein; Guanine nucleotide exchange factor (GEF) which may activate RAB8A and RAB8B . Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form . Mediates the release of GDP from RAB8A and RAB8B but not from RAB3A or RAB5 . Modulates actin organization and promotes polarized transport of RAB8A-specific vesicles to the cell surface . Together with RAB11A, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis . ; Belongs to the SEC2 family.

Synonyms:  RAB3IP,  RAB3IPp,  hRAB3IP,  F8VNX9,  F8VTR6 ...

Linkouts:  STRING  Pharos  UniProt  OMIM