DISEASES

Disease-gene associations mined from literature

Literature on SPSB4

SPSB4 [ENSP00000311609]

SPRY domain-containing SOCS box protein 4; Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins . Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2 . Acts as a bridge which links NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5 . Diminishes EphB2-dependent cell repulsive responses by mediating the ubiquitination and degradation of EphB2/CTF2 . Regulates cellular clock function by mediating the ubiquitin/proteasome-dependent degradation of the circadian transcriptional repressor NR1D1 . ; Belongs to the SPSB family.

Synonyms:  SPSB4,  SPSB4p,  hSPSB4,  H0Y8T2,  Q96A44 ...

Linkouts:  STRING  Pharos  UniProt  OMIM