DISEASES

Disease-gene associations mined from literature

Literature on OAZ2

OAZ2 [ENSP00000463013]

Ornithine decarboxylase antizyme 2; Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimers. Does not target the ODC monomers for degradation, which allows a protein synthesis-independent restoration of ODC activity . Involved in the translocation of AZIN2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol (By similarity).

Synonyms:  OAZ2,  OAZ2p,  hOAZ2,  J3KRW5,  J3KS80 ...

Linkouts:  STRING  Pharos  UniProt  OMIM