DISEASES

Disease-gene associations mined from literature

Literature on COX16

COX16 [ENSP00000374562]

Cytochrome c oxidase assembly protein COX16 homolog, mitochondrial; Required for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase . Promotes the insertion of copper into the active site of cytochrome c oxidase subunit II (MT-CO2/COX2) . Interacts specifically with newly synthesized MT-CO2/COX and its copper center-forming metallochaperones SCO1, SCO2 and COA6 . Probably facilitates MT-CO2/COX2 association with the MITRAC assembly intermediate containing MT- CO1/COX1, thereby participating in merging the MT-CO1/COX1 and MT- CO2/COX2 assembly lines .

Synonyms:  COX16,  COX16p,  hCOX16,  A0A087WX56,  Q9P0S2 ...

Linkouts:  STRING  Pharos  UniProt