DISEASES

Disease-gene associations mined from literature

Literature on SIN3B

SIN3B [ENSP00000369131]

Paired amphipathic helix protein Sin3b; Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription. With FOXK1, regulates cell cycle progression probably by repressing cell cycle inhibitor genes expression.

Synonyms:  SIN3B,  SIN3Bp,  hSIN3B,  M0QYC5,  M0R271 ...

Linkouts:  STRING  Pharos  UniProt  OMIM