DISEASES

Disease-gene associations mined from literature

Literature on HECTD3

HECTD3 [ENSP00000361245]

E3 ubiquitin-protein ligase HECTD3; E3 ubiquitin ligases accepts ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of TRIOBP and its subsequent proteasomal degradation, thus facilitating cell cycle progression by regulating the turn-over of TRIOBP. Mediates also ubiquitination of STX8 (By similarity).

Synonyms:  HECTD3,  HECTD3p,  hHECTD3,  Q5T447,  Q5T447p ...

Linkouts:  STRING  Pharos  UniProt