DISEASES

Disease-gene associations mined from literature

Literature on AREL1

AREL1 [ENSP00000348714]

Apoptosis-resistant E3 ubiquitin protein ligase 1; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits apoptosis by ubiquitinating and targeting for degradation a number of proapoptotic proteins including DIABLO/SMAC, HTRA2 and SEPT4/ARTS which are released from the mitochondrion into the cytosol following apoptotic stimulation.

Synonyms:  AREL1,  AREL1p,  hAREL1,  G3V245,  G3V2B5 ...

Linkouts:  STRING  Pharos  UniProt