DISEASES

Disease-gene associations mined from literature

Literature on FBXL3

FBXL3 [ENSP00000347834]

F-box/LRR-repeat protein 3; Substrate-recognition component of the SCF(FBXL3) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation (PubMed:17463251, PubMed:23452855, PubMed:27565346). The SCF(FBXL3) complex mainly acts in the nucleus and mediates ubiquitination and subsequent degradation of CRY1 and CRY2 . Activity of the SCF(FBXL3) complex is counteracted by the SCF(FBXL21) complex .

Synonyms:  FBXL3,  FBXL3p,  hFBXL3,  C9J0Y7,  Q9UKT7 ...

Linkouts:  STRING  Pharos  UniProt  OMIM