Literature on RNF123
RNF123 [ENSP00000328287]
E3 ubiquitin-protein ligase RNF123; Catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Promotes the ubiquitination and proteasome- mediated degradation of CDKN1B which is the cyclin-dependent kinase inhibitor at the G0-G1 transition of the cell cycle (PubMed:15531880, PubMed:16227581). Functions also as an inhibitor of innate antiviral signaling mediated by DDX58 and IFIH1 independently of its E3 ligase activity . Interacts with the N-terminal CARD domains of DDX58 and IFIH1 and competes with the downstream adapter MAVS .
Synonyms: RNF123, RNF123p, hRNF123, C9J266, C9JI97 ...