DISEASES

Disease-gene associations mined from literature

Literature on PPM1A

PPM1A [ENSP00000327255]

Protein phosphatase 1A; Enzyme with a broad specificity. Negatively regulates TGF- beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha- mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB.

Synonyms:  PPM1A,  PPM1Ap,  hPPM1A,  A0A024R6A5,  E9PJN3 ...

Linkouts:  STRING  Pharos  UniProt  OMIM