DISEASES

Disease-gene associations mined from literature

Literature on EDEM3

EDEM3 [ENSP00000318147]

ER degradation-enhancing alpha-mannosidase-like protein 3; Involved in endoplasmic reticulum-associated degradation (ERAD). Accelerates the glycoprotein ERAD by proteasomes, by catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2 in the N-glycans. Seems to have alpha 1,2-mannosidase activity (By similarity). ; Belongs to the glycosyl hydrolase 47 family.

Synonyms:  EDEM3,  EDEM3p,  hEDEM3,  A0A024R931,  C1orf22 ...

Linkouts:  STRING  Pharos  UniProt  OMIM