DISEASES

Disease-gene associations mined from literature

Literature on ATG4D

ATG4D [ENSP00000311318]

Cysteine protease ATG4D, mitochondrial; [Cysteine protease ATG4D]: Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C- terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms; Belongs to the peptidase C54 family.

Synonyms:  ATG4D,  ATG4Dp,  hATG4D,  K7EJA5,  K7EKP6 ...

Linkouts:  STRING  Pharos  UniProt  OMIM