DISEASES

Disease-gene associations mined from literature

Literature on DOCK5

DOCK5 [ENSP00000276440]

Dedicator of cytokinesis protein 5; Guanine nucleotide exchange factor (GEF) for Rho and Rac. GEF proteins activate small GTPases by exchanging bound GDP for free GTP (By similarity). Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen .

Synonyms:  DOCK5,  DOCK5p,  hDOCK5,  B9A015,  H0Y7N4 ...

Linkouts:  STRING  Pharos  UniProt  OMIM