DISEASES

Disease-gene associations mined from literature

Literature on DLC1

DLC1 [ENSP00000276297]

Rho GTPase-activating protein 7; Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality.

Synonyms:  DLC1,  DLC1p,  hDLC1,  A0A0J9YWS8,  E5RI70 ...

Linkouts:  STRING  Pharos  UniProt  OMIM