DISEASES

Disease-gene associations mined from literature

Literature on WRAP73

WRAP73 [ENSP00000270708]

WD repeat-containing protein WRAP73; The SSX2IP:WRAP73 complex is proposed to act as regulator of spindle anchoring at the mitotic centrosome. Required for the centrosomal localization of SSX2IP and normal mitotic bipolar spindle morphology . Required for the targeting of centriole satellite proteins to centrosomes such as of PCM1, SSX2IP, CEP290 and PIBF1/CEP90. Required for ciliogenesis and involved in the removal of the CEP97:CCP110 complex from the mother centriole. Involved in ciliary vesicle formation at the mother centriole and required for the docking of vesicles to the basal body during ciliogenesis; may promote docking of RAB8A- and ARL13B-containing vesicles .

Synonyms:  WRAP73,  WRAP73p,  hWRAP73,  A0A0A0MRV3,  A0A384MQZ3 ...

Linkouts:  STRING  Pharos  UniProt