Literature on DHX33
DHX33 [ENSP00000225296]
ATP-dependent RNA helicase DHX33; Implicated in nucleolar organization, ribosome biogenesis, protein synthesis and cytoplasmic dsRNA sensing (By similarity) . Stimulates RNA polymerase I transcription of the 47S precursor rRNA. Associates with ribosomal DNA (rDNA) loci where it is involved in POLR1A recruitment . In the cytoplasm, promotes elongation-competent 80S ribosome assembly at the late stage of mRNA translation initiation . Senses cytosolic dsRNA mediating NLRP3 inflammasome formation in macrophages and type I interferon production in myeloid dendritic cells . Required for NLRP3 activation induced by viral dsRNA and bacterial RNA . In dendritic cells, required for induction of type I interferon production induced by cytoplasmic dsRNA via the activation of MAPK and NF-kappa-B signaling pathways (By similarity). ECO:0000269|PubMed:21930779, ECO:0000269|PubMed:23871209,; Belongs to the DEAD box helicase family. DEAH subfamily.
Synonyms: DHX33, DHX33p, hDHX33, I3L0M5, I3L1L6 ...