DISEASES

Disease-gene associations mined from literature

Literature on DNASE2

DNASE2 [ENSP00000222219]

Deoxyribonuclease-2-alpha; Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Plays a major role in the degradation of nuclear DNA in cellular apoptosis during development. Necessary for proper fetal development and for definitive erythropoiesis in fetal liver, where it degrades nuclear DNA expelled from erythroid precursor cells; Belongs to the DNase II family.

Synonyms:  DNASE2,  DNASE2p,  hDNASE2,  A0A024R7F4,  K7ENE5 ...

Linkouts:  STRING  Pharos  UniProt  OMIM