DISEASES

Disease-gene associations mined from literature

Literature on APLP1

APLP1 [ENSP00000221891]

Amyloid-like protein 1; May play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1, activates transcription activation through APBB1 (Fe65) binding (By similarity). Couples to JIP signal transduction through C-terminal binding. May interact with cellular G-protein signaling pathways. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I; Belongs to the APP family.

Synonyms:  APLP1,  APLP1p,  hAPLP1,  B7Z4G8,  F5GZ08 ...

Linkouts:  STRING  Pharos  UniProt  OMIM