DISEASES

Disease-gene associations mined from literature

Literature on RNF125

RNF125 [ENSP00000217740]

E3 ubiquitin-protein ligase RNF125; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins, such as DDX58/RIG-I, MAVS/IPS1, IFIH1/MDA5, JAK1 and p53/TP53 (PubMed:15843525, PubMed:17460044, PubMed:17643463, PubMed:26027934, PubMed:26471729, PubMed:25591766, PubMed:27411375). Acts as a negative regulator of type I interferon production by mediating ubiquitination of DDX58/RIG-I at 'Lys-181', leading to DDX58/RIG-I degradation (PubMed:17460044, PubMed:26471729). Mediates ubiquitination and subsequent degradation of p53/TP53 . Mediates ubiquitination and subsequent degradation of JAK1 . Acts as a positive regulator of T-cell activation . ECO:0000269|PubMed:17460044, ECO:0000269|PubMed:17643463, ECO:0000269|PubMed:25591766, ECO:0000269|PubMed:26027934,

Synonyms:  RNF125,  RNF125p,  hRNF125,  J3QQW8,  Q96EQ8 ...

Linkouts:  STRING  Pharos  UniProt  OMIM