DISEASES

Disease-gene associations mined from literature

Literature on ST14

ST14 [ENSP00000278742]

Suppressor of tumorigenicity 14 protein; Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site. Involved in the terminal differentiation of keratinocytes through prostasin (PRSS8) activation and filaggrin (FLG) processing.

Synonyms:  ST14,  ST14p,  hST14,  Q9Y5Y6,  Q9Y5Y6p ...

Linkouts:  STRING  Pharos  UniProt  OMIM