DISEASES

Disease-gene associations mined from literature

Literature on PPP1R1A

PPP1R1A [ENSP00000257905]

Protein phosphatase 1 regulatory subunit 1A; Inhibitor of protein-phosphatase 1. This protein may be important in hormonal control of glycogen metabolism. Hormones that elevate intracellular cAMP increase I-1 activity in many tissues. I-1 activation may impose cAMP control over proteins that are not directly phosphorylated by PKA. Following a rise in intracellular calcium, I-1 is inactivated by calcineurin (or PP2B). Does not inhibit type-2 phosphatases.

Synonyms:  PPP1R1A,  PPP1R1Ap,  hPPP1R1A,  F8VR76,  H0YIU4 ...

Linkouts:  STRING  Pharos  UniProt  OMIM