DISEASES

Disease-gene associations mined from literature

Literature on VPS54

VPS54 [ENSP00000272322]

Vacuolar protein sorting-associated protein 54; Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD . Within the GARP complex, required to tether the complex to the TGN. Not involved in endocytic recycling ; Belongs to the VPS54 family.

Synonyms:  VPS54,  VPS54p,  hVPS54,  A0A0A0MT48,  Q9P1Q0 ...

Linkouts:  STRING  Pharos  UniProt  OMIM