DISEASES

Disease-gene associations mined from literature

Literature on ZWILCH

ZWILCH [ENSP00000311429]

Protein zwilch homolog; Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex . ; Belongs to the ZWILCH family.

Synonyms:  ZWILCH,  H3BPI7,  H3BQ07,  H3BSG1,  Q9H900 ...

Linkouts:  STRING  Pharos  UniProt  OMIM