DISEASES

Disease-gene associations mined from literature

Literature on SLF1

SLF1 [ENSP00000265140]

SMC5-SMC6 complex localization factor protein 1; Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance . The SLF1-SLF2 complex acts to link RAD18 with the SMC5-SMC6 complex at replication-coupled interstrand cross-links (ICL) and DNA double-strand breaks (DSBs) sites on chromatin during DNA repair in response to stalled replication forks . Promotes the recruitment of SLF2 and the SMC5-SMC6 complex to DNA lesions .

Synonyms:  SLF1,  SLF1p,  hSLF1,  D6RED9,  H0YBU1 ...

Linkouts:  STRING  Pharos  UniProt