DISEASES

Disease-gene associations mined from literature

Literature on KIF13A

KIF13A [ENSP00000259711]

Kinesin-like protein KIF13A; Plus end-directed microtubule-dependent motor protein involved in intracellular transport and regulating various processes such as mannose-6-phosphate receptor (M6PR) transport to the plasma membrane, endosomal sorting during melanosome biogenesis and cytokinesis. Mediates the transport of M6PR-containing vesicles from trans-Golgi network to the plasma membrane via direct interaction with the AP-1 complex. During melanosome maturation, required for delivering melanogenic enzymes from recycling endosomes to nascent melanosomes by creating peripheral recycling endosomal subdomains in melanocytes. Also required for the abcission step in cytokinesis: mediates translocation of ZFYVE26, and possibly TTC19, to the midbody during cytokinesis.

Synonyms:  KIF13A,  KIF13Ap,  hKIF13A,  A0A1B0GUA8,  H0Y307 ...

Linkouts:  STRING  Pharos  UniProt  OMIM