DISEASES

Disease-gene associations mined from literature

Literature on GRSF1

GRSF1 [ENSP00000254799]

G-rich sequence factor 1; Regulator of post-transcriptional mitochondrial gene expression, required for assembly of the mitochondrial ribosome and for recruitment of mRNA and lncRNA. Binds RNAs containing the 14 base G- rich element. Preferentially binds RNAs transcribed from three contiguous genes on the light strand of mtDNA, the ND6 mRNA, and the long non-coding RNAs for MT-CYB and MT-ND5, each of which contains multiple consensus binding sequences (PubMed:23473033, PubMed:23473034, PubMed:29967381). Involved in the degradosome-mediated decay of non- coding mitochondrial transcripts (MT-ncRNA) and tRNA-like molecules . Acts by unwinding G-quadruplex RNA structures in MT- ncRNA, thus facilitating their degradation by the degradosome . G-quadruplexes (G4) are non-canonical 4 stranded structures formed by transcripts from the light strand of mtDNA .

Synonyms:  GRSF1,  GRSF1p,  hGRSF1,  A0A024RD99,  F5H5I6 ...

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