DISEASES

Disease-gene associations mined from literature

Literature on TDRD12

TDRD12 [ENSP00000390621]

Putative ATP-dependent RNA helicase TDRD12; Probable ATP-binding RNA helicase required during spermatogenesis to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Involved in the secondary piRNAs metabolic process. Acts via the PET complex, a multiprotein complex required during the secondary piRNAs metabolic process for the PIWIL2 slicing- triggered loading of PIWIL4 piRNAs.

Synonyms:  TDRD12,  TDRD12p,  hTDRD12,  A0A1B0GU57,  A0A1W2PRK2 ...

Linkouts:  STRING  Pharos  UniProt