DISEASES

Disease-gene associations mined from literature

Literature on FAM162A

FAM162A [ENSP00000419088]

Protein FAM162A; Proposed to be involved in regulation of apoptosis; the exact mechanism may differ between cell types/tissues. May be involved in hypoxia-induced cell death of transformed cells implicating cytochrome C release and caspase activation (such as CASP9) and inducing mitochondrial permeability transition. May be involved in hypoxia- induced cell death of neuronal cells probably by promoting release of AIFM1 from mitochondria to cytoplasm and its translocation to the nucleus; however, the involvement of caspases has been reported conflictingly.

Synonyms:  FAM162A,  FAM162Ap,  hFAM162A,  E9PH05,  F8W7Q4 ...

Linkouts:  STRING  Pharos  UniProt  OMIM