DISEASES

Disease-gene associations mined from literature

Literature on DUSP7

DUSP7 [ENSP00000417183]

Dual specificity protein phosphatase 7; Dual specificity protein phosphatase . Shows high activity towards MAPK1/ERK2 . Also has lower activity towards MAPK14 and MAPK8 . In arrested oocytes, plays a role in meiotic resumption (By similarity). Promotes nuclear envelope breakdown and activation of the CDK1/Cyclin-B complex in oocytes, probably by dephosphorylating and inactivating the conventional protein kinase C (cPKC) isozyme PRKCB (By similarity). May also inactivate PRKCA and/or PRKCG (By similarity). Also important in oocytes for normal chromosome alignment on the metaphase plate and progression to anaphase, where it might regulate activity of the spindle-assembly checkpoint (SAC) complex (By similarity).

Synonyms:  DUSP7,  DUSP7p,  hDUSP7,  H7C4Z0,  Q16829 ...

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