DISEASES

Disease-gene associations mined from literature

Literature on SIGLEC11

SIGLEC11 [ENSP00000412361]

Sialic acid-binding Ig-like lectin 11; Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,8-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules.

Synonyms:  SIGLEC11,  H7C2S0,  Q96RL6,  H7C2S0p,  hH7C2S0 ...

Linkouts:  STRING  Pharos  UniProt  OMIM