DISEASES

Disease-gene associations mined from literature

Literature on SHISA6

SHISA6 [ENSP00000390084]

Protein shisa-6; Involved in maintenance of high-frequency synaptic transmission at hippocampal CA3-CA1 synapses. Regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated state in the presence of glutamate and preventing synaptic depression. May play a role in self-renewal and differentiation of spermatogonial stem cells by inhibiting canonical Wnt signaling pathway.

Synonyms:  SHISA6,  SHISA6p,  hSHISA6,  Q6ZSJ9,  V9GZ25 ...

Linkouts:  STRING  Pharos  UniProt