DISEASES

Disease-gene associations mined from literature

Literature on MAP3K1

MAP3K1 [ENSP00000382423]

Mitogen-activated protein kinase kinase kinase 1; Component of a protein kinase signal transduction cascade . Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4 . May phosphorylate the MAPK8/JNK1 kinase . Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway .

Synonyms:  MAP3K1,  MAP3K1p,  hMAP3K1,  Q13233,  Q13233p ...

Linkouts:  STRING  Pharos  UniProt  OMIM