DISEASES

Disease-gene associations mined from literature

Literature on CAMSAP1

CAMSAP1 [ENSP00000374183]

Calmodulin-regulated spectrin-associated protein 1; Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19508979, PubMed:21834987, PubMed:24486153, PubMed:24706919, PubMed:24117850). Specifically recognizes growing microtubule minus-ends and stabilizes microtubules . Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization . In contrast to CAMSAP2 and CAMSAP3, tracks along the growing tips of minus-end microtubules without significantly affecting the polymerization rate: binds at the very tip of the microtubules minus-end and acts as a minus-end tracking protein (-TIP) that dissociates from microtubules after allowing tubulin incorporation . Through interaction with spectrin may regulate neurite outgrowth . ECO:0000269|PubMed:24117850, ECO:0000269|PubMed:24486153,

Synonyms:  CAMSAP1,  CAMSAP1p,  hCAMSAP1,  A0A384NY94,  Q5T5Y3 ...

Linkouts:  STRING  Pharos  UniProt  OMIM