DISEASES

Disease-gene associations mined from literature

Literature on TRIM6

TRIM6 [ENSP00000369440]

Tripartite motif-containing protein 6; E3 ubiquitin-protein ligase which ubiquitinates MYC and inhibits its transcription activation activity, maintaining the pluripotency of embryonic stem cells (By similarity). Involved in the synthesis of unanchored K48-linked polyubiquitin chains which interact with and activate the serine/threonine kinase IKBKE, leading to phosphorylation of STAT1 and stimulation of an antiviral response ; Belongs to the TRIM/RBCC family.

Synonyms:  TRIM6,  TRIM6p,  hTRIM6,  C9JNQ0,  E9PFM0 ...

Linkouts:  STRING  Pharos  UniProt  OMIM