DISEASES

Disease-gene associations mined from literature

Literature on TRUB2

TRUB2 [ENSP00000361982]

Mitochondrial mRNA pseudouridine synthase TRUB2; Minor enzyme contributing to the isomerization of uridine to pseudouridine (pseudouridylation) of specific mitochondrial mRNAs (mt- mRNAs) such as COXI and COXIII mt-mRNAs . As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation .

Synonyms:  TRUB2,  TRUB2p,  hTRUB2,  A0A024R886,  O95900 ...

Linkouts:  STRING  Pharos  UniProt  OMIM