DISEASES

Disease-gene associations mined from literature

Literature on MFNG

MFNG [ENSP00000349490]

Beta-1,3-N-acetylglucosaminyltransferase manic fringe; Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules . Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in inhibition of NOTCH1 activation by JAG1 and enhancement of NOTCH1 activation by DLL1 via an increase in its binding to DLL1 (By similarity).

Synonyms:  MFNG,  A0A1B0GX02,  A9UJP9,  A9UJQ1,  F8WE05 ...

Linkouts:  STRING  Pharos  UniProt  OMIM