DISEASES

Disease-gene associations mined from literature

Literature on ENSA

ENSA [ENSP00000341743]

Alpha-endosulfine; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (By similarity). Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents.

Synonyms:  ENSA,  A0A1W2PRU0,  A6NMQ3,  O43768,  Q5T5H1 ...

Linkouts:  STRING  Pharos  UniProt  OMIM