DISEASES

Disease-gene associations mined from literature

Literature on UBE2O

UBE2O [ENSP00000323687]

(E3-independent) E2 ubiquitin-conjugating enzyme; E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins . Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity . Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis . Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellular location . Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate 'Lys-63'-linked ubiquitination of WASHC1, leading to promote endosomal F-actin assembly . ; Belongs to the ubiquitin-conjugating enzyme family.

Synonyms:  UBE2O,  UBE2Op,  hUBE2O,  K7EQ12,  K7ES11 ...

Linkouts:  STRING  Pharos  UniProt