DISEASES

Disease-gene associations mined from literature

Literature on CIAO2A

CIAO2A [ENSP00000300030]

Cytosolic iron-sulfur assembly component 2A; Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins . As a CIA complex component and in collaboration with CIAO1 specifically matures ACO1 and stabilizes IREB2, connecting cytosolic iron-sulfur protein maturation with cellular iron regulation . May play a role in chromosome segregation through establishment of sister chromatid cohesion. May induce apoptosis in collaboration with APAF1 ; Belongs to the MIP18 family.

Synonyms:  CIAO2A,  CIAO2Ap,  hCIAO2A,  H0YKV4,  H0YLH6 ...

Linkouts:  STRING  Pharos  UniProt