DISEASES

Disease-gene associations mined from literature

Literature on STXBP5L

STXBP5L [ENSP00000273666]

Syntaxin-binding protein 5-like; Plays a role in vesicle trafficking and exocytosis inhibition. In pancreatic beta-cells, inhibits insulin secretion probably by interacting with and regulating STX1A and STX4, key t-SNARE proteins involved in the fusion of insulin granules to the plasma membrane. Plays also a role in neurotransmitter release by inhibiting basal acetylcholine release from axon terminals and by preventing synaptic fatigue upon repetitive stimulation (By similarity). Promotes as well axonal outgrowth .

Synonyms:  STXBP5L,  STXBP5Lp,  hSTXBP5L,  C9JCY1,  C9JPK3 ...

Linkouts:  STRING  Pharos  UniProt  OMIM