DISEASES

Disease-gene associations mined from literature

Literature on MARCHF9

MARCHF9 [ENSP00000266643]

E3 ubiquitin-protein ligase MARCHF9; E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I, CD4 and ICAM1, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.

Synonyms:  MARCHF9,  MARCHF9p,  hMARCHF9,  MARCH9,  Q86YJ5 ...

Linkouts:  STRING  Pharos  UniProt  OMIM