DISEASES

Disease-gene associations mined from literature

Literature on SPPL2A

SPPL2A [ENSP00000261854]

Signal peptide peptidase-like 2A; Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in FASLG, ITM2B and TNF processing . Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus . Also responsible for the intramembrane cleavage of Fas antigen ligand FASLG, which promotes the release of the intracellular FasL domain (FasL ICD) . May play a role in the regulation of innate and adaptive immunity . Catalyzes the intramembrane cleavage of the simian foamy virus envelope glycoprotein gp130 independently of prior ectodomain shedding by furin or furin-like proprotein convertase (PC)-mediated cleavage proteolysis . ECO:0000269|PubMed:16829952, ECO:0000269|PubMed:17557115,

Synonyms:  SPPL2A,  SPPL2Ap,  hSPPL2A,  H0YNA2,  H0YNA7 ...

Linkouts:  STRING  Pharos  UniProt